A prolonged and dangerous heatwave is bearing down on the central and eastern United States ahead of the Fourth of July weekend, with the National Weather Service warning heat index values could climb to 115°F in the hardest-hit areas.

The NWS issued warnings Wednesday as temperatures across a broad stretch of the country were already running well above seasonal norms, with conditions set to worsen through the holiday period.

Heat index readings — which combine air temperature with humidity to reflect how the heat actually feels — are forecast to remain at life-threatening levels for multiple consecutive days across parts of the region.

Public health agencies warn that extreme heat kills more Americans annually than any other weather event. The elderly, young children, outdoor workers, and those without access to air conditioning face the greatest danger.

Emergency cooling centers are being activated in several cities ahead of the weekend surge. Officials are urging residents to stay hydrated, avoid midday sun, and check on vulnerable neighbors.

The heatwave is expected to peak through the Fourth of July weekend, with forecasters monitoring conditions into early next week.